%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Chokephaibulkit, K.
%A Kariminia, A.
%A Oberdorfer, P.
%A Nallusamy, R.
%A Jourdain, Gonzague
%A et al.
%T Characterizing HIV manifestations and treatment outcomes of perinatally infected adolescents in Asia
%D 2014
%L fdi:010069735
%G ENG
%J Pediatric Infectious Diseases Journal
%@ 0891-3668
%K ASIE ; CAMBODGE ; INDE ; INDONESIE ; MALAISIE ; THAILANDE ; VIET NAM
%M ISI:000331699000020
%N 3
%P 291-294
%U https://www.documentation.ird.fr/hor/fdi:010069735
%> https://www.documentation.ird.fr/intranet/publi/depot/2017-04-20/010069735.pdf
%V 33
%W Horizon (IRD)
%X Background: More perinatally HIV-infected children in Asia are reaching adolescence. Methods: We analyzed data from July 1991 to March 2011 reported by 18 clinics in 6 countries of children age >12 years. Results: Of 1254 adolescents, 33 (2.6%) died, and 52 (4.1%) were lost to follow-up within 2.4-year (3566 person-years) median follow-up period. Of 1061 adolescents under active follow-up, 485 (46%) were male, median (interquartile range) age was 14.7 (13.3-16.4) years, 73% had lost a parent(s), 93% attended school and 62% were aware of their HIV status. At the most recent evaluation, 93% were receiving highly active antiretroviral therapy, 71% (N = 737/1035) had CD4 500 cells/mm(3) and 87% (N = 718/830) had viral load (VL) <400 copies/mL. Current CD4 200 cells/mm(3), no previous World Health Organization stage 3 or 4 and being on a first-line regimen were independently associated with recent VL <400 copies/mL. Current age <15 years, VL <400 copies/mL, CD4 15-24% (vs. <10%) at antiretroviral therapy initiation, no previous World Health Organization stage 3 or 4 and antiretroviral therapy duration of 1 year were associated with recent CD4 500 cells/mm(3). Primary causes of death after age 12 were opportunistic infections (N = 15/33) and other AIDS- or treatment-related conditions (N = 9/33). Those at age 12 with CD4 <200 versus 500 cells/mm(3) and those with VL 10,000 versus <10,000 copies/mL were 17.4 and 4.76 times more likely to die in adolescence, respectively.
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