@article{fdi:010069735,
  title = {{C}haracterizing {HIV} manifestations and treatment outcomes of perinatally infected adolescents in {A}sia},
  author = {{C}hokephaibulkit, {K}. and {K}ariminia, {A}. and {O}berdorfer, {P}. and {N}allusamy, {R}. and {J}ourdain, {G}onzague and et al.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}ore perinatally {HIV}-infected children in {A}sia are reaching adolescence. {M}ethods: {W}e analyzed data from {J}uly 1991 to {M}arch 2011 reported by 18 clinics in 6 countries of children age >12 years. {R}esults: {O}f 1254 adolescents, 33 (2.6%) died, and 52 (4.1%) were lost to follow-up within 2.4-year (3566 person-years) median follow-up period. {O}f 1061 adolescents under active follow-up, 485 (46%) were male, median (interquartile range) age was 14.7 (13.3-16.4) years, 73% had lost a parent(s), 93% attended school and 62% were aware of their {HIV} status. {A}t the most recent evaluation, 93% were receiving highly active antiretroviral therapy, 71% ({N} = 737/1035) had {CD}4 500 cells/mm(3) and 87% ({N} = 718/830) had viral load ({VL}) <400 copies/m{L}. {C}urrent {CD}4 200 cells/mm(3), no previous {W}orld {H}ealth {O}rganization stage 3 or 4 and being on a first-line regimen were independently associated with recent {VL} <400 copies/m{L}. {C}urrent age <15 years, {VL} <400 copies/m{L}, {CD}4 15-24% (vs. <10%) at antiretroviral therapy initiation, no previous {W}orld {H}ealth {O}rganization stage 3 or 4 and antiretroviral therapy duration of 1 year were associated with recent {CD}4 500 cells/mm(3). {P}rimary causes of death after age 12 were opportunistic infections ({N} = 15/33) and other {AIDS}- or treatment-related conditions ({N} = 9/33). {T}hose at age 12 with {CD}4 <200 versus 500 cells/mm(3) and those with {VL} 10,000 versus <10,000 copies/m{L} were 17.4 and 4.76 times more likely to die in adolescence, respectively.},
  keywords = {{ASIE} ; {CAMBODGE} ; {INDE} ; {INDONESIE} ; {MALAISIE} ; {THAILANDE} ; {VIET} {NAM}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}iseases {J}ournal},
  volume = {33},
  numero = {3},
  pages = {291--294},
  ISSN = {0891-3668},
  year = {2014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069735},
}