@article{fdi:010069610,
  title = {{M}ycobacterium tuberculosis : ecology and evolution of a human bacterium},
  author = {{B}anuls, {A}nne-{L}aure and {S}anou, {A}. and {A}nh, {N}. {T}. {V}. and {G}odreuil, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ome species of the {M}ycobacterium tuberculosis complex ({MTBC}), particularly {M}ycobacterium tuberculosis, which causes human tuberculosis ({TB}), are the first cause of death linked to a single pathogen worldwide. {I}n the last decades, evolutionary studies have much improved our knowledge on {MTBC} history and have highlighted its long co-evolution with humans. {I}ts ability to remain latent in humans, the extraordinary proportion of asymptomatic carriers (one-third of the entire human population), the deadly epidemics and the observed increasing level of resistance to antibiotics are proof of its evolutionary success. {M}any {MTBC} molecular signatures show not only that these bacteria are a model of adaptation to humans but also that they have influenced human evolution. {O}wing to the unbalance between the number of asymptomatic carriers and the number of patients with active {TB}, some authors suggest that infection by {MTBC} could have a protective role against active {TB} disease and also against other pathologies. {H}owever, it would be inappropriate to consider these infectious pathogens as commensals or symbionts, given the level of morbidity and mortality caused by {TB}.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {M}edical {M}icrobiology},
  volume = {64},
  numero = {11},
  pages = {1261--1269},
  ISSN = {0022-2615},
  year = {2015},
  DOI = {10.1099/jmm.0.000171},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069610},
}