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Cames Cécile, Pascal Léa, Diack A., Mbodj H., Ouattara B., Diagne N. R., Diallo N. F., Msellati Philippe, Mbaye N., Signate H. S., Maggsen Cohort Study Group. (2017). Factors for growth retardation in HIV-infected Senegalese children on antiretroviral treatment The ANRS 12279 MAGGSEN pediatric cohort study. Pediatric Infectious Disease Journal, 36 (4), E87-E92. ISSN 0891-3668

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Lien direct chez l'éditeur doi:10.1097/inf.0000000000001454

Titre
Factors for growth retardation in HIV-infected Senegalese children on antiretroviral treatment The ANRS 12279 MAGGSEN pediatric cohort study
Année de publication2017
Type de documentArticle référencé dans le Web of Science WOS:000396222900002
AuteursCames Cécile, Pascal Léa, Diack A., Mbodj H., Ouattara B., Diagne N. R., Diallo N. F., Msellati Philippe, Mbaye N., Signate H. S., Maggsen Cohort Study Group.
SourcePediatric Infectious Disease Journal, 2017, 36 (4), p. E87-E92. ISSN 0891-3668
RésuméObjectives: To describe prevalence and risk factors for wasting and stunting among HIV-infected children with a median duration of 3 years of antiretroviral therapy (ART) at the time of their enrollment in the cohort study. Methods: Wasting and stunting at ART initiation and enrollment were defined as weight-for-height/body mass index-for-age Z scores <-2 and height-forage Z scores <-2, respectively. Logistic regression was used to assess risk factors for wasting and stunting. Main predictive factors were age at enrollment, nutritional status and age (< or >= 5 years) at ART initiation and ART duration (< or >= 3 years on first-line, or >= 3 years including a switch to second-line ART). Results: Two hundred forty-four children 2-16 years of age were enrolled. Overall, wasting and stunting prevalence dropped off consistently in children 2-10 years of age, between ART initiation and enrollment, while it remained at high levels, 52% and 42%, respectively, in children 10-16 years of age. Risk factors for wasting at enrollment were ART duration of >= 3 years including a switch to second-line [adjusted odds ratio (aOR): 3.9, 95% confidence interval (CI): 1.7-8.9] and wasting at ART initiation (aOR: 2.7, 95% CI: 1.4-5.2). The risk factor for stunting at enrollment was stunting at ART initiation (aOR: 11.6, 95% CI: 5.4-25.0), independent of ART duration. Conclusions: Malnutrition at the time of ART initiation was the main predictor of malnutrition at enrollment among HIV-infected children on ART. Longer duration on ART had no overall protective effect on wasting and stunting. Growth and virologic monitoring are of utmost importance in the comprehensive care of children with HIV infection.
Plan de classementSanté : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Descr. géo.SENEGAL
LocalisationFonds IRD [F B010069499]
Identifiant IRDfdi:010069499
Lien permanenthttp://www.documentation.ird.fr/hor/fdi:010069499

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