@article{fdi:010069463,
  title = {{T}he {L}ipid{A} from {R}hodopseudomonas palustris strain {B}is{A}53 {LPS} possesses a unique structure and low immunostimulant properties},
  author = {{D}i {L}orenzo, {F}. and {P}almigiano, {A}. and {A}l {B}itar-{N}ehme, {S}. and {S}turiale, {L}. and {D}uda, {K}. {A}. and {G}ully, {D}jamel and {L}anzetta, {R}. and {G}iraud, {E}ric and {G}arozzo, {D}. and {B}ernardini, {M}. {L}. and {M}olinaro, {A}. and {S}ilipo, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he search for novel lipid{A} analogues from any biological source that can act as antagonists, displaying inhibitory activity towards the production of pro-inflammatory cytokines, or as immunomodulators in mammals, is a very topical issue. {T}o this aim, the structure and immunological properties of the lipopolysaccharide lipid{A} from the purple nonsulfur bacterium {R}hodopseudomonas palustris strain {B}is{A}53 have been determined. {T}his lipid{A} displays a unique structural feature, with a non-phosphorylated skeleton made up of the tetrasaccharide {M}anp--(14)-{G}lcp{N}3{N}--16-{G}lcp{N}3{N}--(11)--{G}alp{A}, and four primary amide-linked 14:0(3-{OH}) and, as secondary {O}-acyl substituents, a 16:0 and the very long-chain fatty acid 26:0(25-{OA}c), appended on the {G}lcp{N}3{N} units. {T}his lipid{A} architecture is definitely rare, so far identified only in the genus {B}radyrhizobium. {I}mmunological tests on both murine bone-marrow-derived and human monocyte-derived macrophages revealed an extremely low immunostimulant capability of this {LPS} lipid{A}.},
  keywords = {fatty acids ; glycolipids ; innate immunity ; lipopolysaccharides ; {NMR} ; spectroscopy},
  booktitle = {},
  journal = {{C}hemistry : {E}uropean {J}ournal},
  volume = {23},
  numero = {15},
  pages = {3637--3647},
  ISSN = {0947-6539},
  year = {2017},
  DOI = {10.1002/chem.201604379},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069463},
}