Publications des scientifiques de l'IRD

Di Lorenzo F., Palmigiano A., Al Bitar-Nehme S., Sturiale L., Duda K. A., Gully Djamel, Lanzetta R., Giraud Eric, Garozzo D., Bernardini M. L., Molinaro A., Silipo A. (2017). The LipidA from Rhodopseudomonas palustris strain BisA53 LPS possesses a unique structure and low immunostimulant properties. Chemistry : European Journal, 23 (15), p. 3637-3647. ISSN 0947-6539.

Titre du document
The LipidA from Rhodopseudomonas palustris strain BisA53 LPS possesses a unique structure and low immunostimulant properties
Année de publication
2017
Type de document
Article référencé dans le Web of Science WOS:000397502900016
Auteurs
Di Lorenzo F., Palmigiano A., Al Bitar-Nehme S., Sturiale L., Duda K. A., Gully Djamel, Lanzetta R., Giraud Eric, Garozzo D., Bernardini M. L., Molinaro A., Silipo A.
Source
Chemistry : European Journal, 2017, 23 (15), p. 3637-3647 ISSN 0947-6539
The search for novel lipidA analogues from any biological source that can act as antagonists, displaying inhibitory activity towards the production of pro-inflammatory cytokines, or as immunomodulators in mammals, is a very topical issue. To this aim, the structure and immunological properties of the lipopolysaccharide lipidA from the purple nonsulfur bacterium Rhodopseudomonas palustris strain BisA53 have been determined. This lipidA displays a unique structural feature, with a non-phosphorylated skeleton made up of the tetrasaccharide Manp--(14)-GlcpN3N--16-GlcpN3N--(11)--GalpA, and four primary amide-linked 14:0(3-OH) and, as secondary O-acyl substituents, a 16:0 and the very long-chain fatty acid 26:0(25-OAc), appended on the GlcpN3N units. This lipidA architecture is definitely rare, so far identified only in the genus Bradyrhizobium. Immunological tests on both murine bone-marrow-derived and human monocyte-derived macrophages revealed an extremely low immunostimulant capability of this LPS lipidA.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Biotechnologies [084]
Localisation
Fonds IRD [F B010069463]
Identifiant IRD
fdi:010069463
Contact