%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Doménech-Carbo, A.
%A Rodrigo, R.
%A Maréchal, J. D.
%A Poupon, E.
%A Fournet, Alain
%A Figadère, B.
%A Cebrian-Torrejon, G.
%T Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural beta-carboline canthin-6-one
%D 2017
%L fdi:010069426
%G ENG
%J Journal of Molecular Structure
%@ 0022-2860
%M ISI:000394919100075
%P 661-667
%R 10.1016/j.molstruc.2016.12.016
%U https://www.documentation.ird.fr/hor/fdi:010069426
%> https://www.documentation.ird.fr/intranet/publi/2017/04/010069426.pdf
%V 1134
%W Horizon (IRD)
%X The inhibition of soluble guanylate cyclase (sGC) by canthin-6-one alkaloid (L1) is presented and the mechanism of deactivation is studied using solution phase and voltammetry of microparticles methodologies. Possible inhibition pathways: oxidation of Fe2+ to Fe3+ coupled to reduction of the naphthyridone motif present by the canthin-6-one and coordinating or reacting of L1 with cysteine units of sGC, are balanced.
%$ 020