Doménech-Carbo A., Rodrigo R., Maréchal J. D., Poupon E., Fournet Alain, Figadère B., Cebrian-Torrejon G. (2017). Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural beta-carboline canthin-6-one. Journal of Molecular Structure, 1134, p. 661-667. ISSN 0022-2860.
Titre du document
Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural beta-carboline canthin-6-one
Doménech-Carbo A., Rodrigo R., Maréchal J. D., Poupon E., Fournet Alain, Figadère B., Cebrian-Torrejon G.
Source
Journal of Molecular Structure, 2017,
1134, p. 661-667 ISSN 0022-2860
The inhibition of soluble guanylate cyclase (sGC) by canthin-6-one alkaloid (L1) is presented and the mechanism of deactivation is studied using solution phase and voltammetry of microparticles methodologies. Possible inhibition pathways: oxidation of Fe2+ to Fe3+ coupled to reduction of the naphthyridone motif present by the canthin-6-one and coordinating or reacting of L1 with cysteine units of sGC, are balanced.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
