@article{fdi:010069364,
  title = {{P}osttreatment reactions after single-dose diethylcarbamazine or ivermectin in subjects with {L}oa loa infection},
  author = {{H}errick, {J}. {A}. and {L}egrand, {F}. and {G}ounoue, {R}. and {N}chinda, {G}. and {M}ontavon, {C}{\'e}line and {B}opda, {J}. and {T}chana, {S}. {M}. and {O}ndigui, {B}. {E}. and {N}guluwe, {K}. and {F}ay, {M}. {P}. and {M}akiya, {M}. and {M}etenou, {S}. and {N}utman, {T}. {B}. and {K}amgno, {J}. and {K}lion, {A}. {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {S}evere adverse reactions have been observed in individuals with {L}oa loa infection treated with either diethylcarbamazine ({DEC}), the drug of choice for loiasis, or ivermectin ({IVM}), which is used in mass drug administration programs for control of onchocerciasis and lymphatic filariasis in {A}frica. {I}n this study, posttreatment clinical and immunologic reactions were compared following single-dose therapy with {DEC} or {IVM} to assess whether these reactions have the same underlying pathophysiology. {M}ethods. {T}welve patients with loiasis and microfilarial counts < 2000 mf/m{L} were randomized to receive single-dose {DEC} (8 mg/kg) or {IVM} (200 mu g/kg). {C}linical and laboratory assessments were performed at 4, 8, 24, 48, and 72 hours and 5, 7, 9, and 14 days posttreatment. {R}esults. {P}osttreatment adverse events were similar following {DEC} or {IVM}, but peaked earlier in subjects who received {DEC}, consistent with a trend toward more rapid and complete microfilarial clearance in the {DEC} group. {A}fter a transient rise (post-{IVM}) or fall (post-{DEC}) in the first 24 hours posttreatment, the eosinophil count rose significantly in both groups, peaking at day 5 in the {DEC} group and day 9 in the {IVM} group. {S}erum interleukin 5 levels and eosinophil activation, as assessed by surface expression of {CD}69 and serum levels of eosinophil granule proteins, were increased posttreatment in both groups. {C}onclusions. {D}espite differences in eosinophil and lymphocyte counts during the first 24 hours posttreatment, the overall pattern of hematologic and immunologic changes suggest that posttreatment reactions following {DEC} and {IVM} share a common pathophysiology.},
  keywords = {{L}oa loa ; ivermectin ; diethylcarbamazine ; eosinophil ; filariasis ; {CAMEROUN}},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {64},
  numero = {8},
  pages = {1017--1025},
  ISSN = {1058-4838},
  year = {2017},
  DOI = {10.1093/cid/cix016},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069364},
}