@article{fdi:010069304,
  title = {{P}lasmodium malariae and {P}. ovale genomes provide insights into malaria parasite evolution},
  author = {{R}utledge, {G}. {G}. and {B}ohme, {U}. and {S}anders, {M}. and {R}rid, {A}. {J}. and {C}otton, {J}. {A}. and {M}aiga-{A}scofare, {O}. and {D}jimd{\'e}, {A}. {A}. and {A}pinjoh, {T}. {O}. and {A}menga-{E}tego, {L}. and {M}anske, {M}. and {B}arnwell, {J}. {W}. and {R}enaud, {F}. and {O}llomo, {B}. and {P}rugnolle, {F}ranck and {A}nstey, {N}. {M}. and {A}uburn, {S}. and {P}rice, {R}. {N}. and {M}c{C}arthy, {J}. {S}. and {K}wiatkowski, {D}. {P}. and {N}ewbold, {C}. {I}. and {B}erriman, {M}. and {O}tto, {T}. {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}lucidation of the evolutionary history and interrelatedness of {P}lasmodium species that infect humans has been hampered by a lack of genetic information for three human-infective species: {P}. malariae and two {P}. ovale species ({P}. o. curtisi and {P}. o. wallikeri)(1). {T}hese species are prevalent across most regions in which malaria is endemic(2,3) and are often undetectable by light microscopy(4), rendering their study in human populations difficult(5). {T}he exact evolutionary relationship of these species to the other human-infective species has been contested(6,7). {U}sing a new reference genome for {P}. malariae and a manually curated draft {P}. o. curtisi genome, we are now able to accurately place these species within the {P}lasmodium phylogeny. {S}equencing of a {P}. malariae relative that infects chimpanzees reveals similar signatures of selection in the {P}. malariae lineage to another {P}lasmodium lineage shown to be capable of colonization of both human and chimpanzee hosts. {M}olecular dating suggests that these host adaptations occurred over similar evolutionary timescales. {I}n addition to the core genome that is conserved between species, differences in gene content can be linked to their specific biology. {T}he genome suggests that {P}. malariae expresses a family of heterodimeric proteins on its surface that have structural similarities to a protein crucial for invasion of red blood cells. {T}he data presented here provide insight into the evolution of the {P}lasmodium genus as a whole.},
  keywords = {{ZONE} {TROPICALE}},
  booktitle = {},
  journal = {{N}ature},
  volume = {542},
  numero = {7639},
  pages = {101--104 +16 p.},
  ISSN = {0028-0836},
  year = {2017},
  DOI = {10.1038/nature21038},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069304},
}