Eldin C., Melenotte C., Mediannikov Oleg, Ghigo E., Million M., Edouard S., Mege J. L., Maurin M., Raoult D. (2017). From Q fever to Coxiella burnetii infection : a paradigm change. Clinical Microbiology Reviews, 30 (1), p. 115-190. ISSN 0893-8512.
Titre du document
From Q fever to Coxiella burnetii infection : a paradigm change
Année de publication
2017
Auteurs
Eldin C., Melenotte C., Mediannikov Oleg, Ghigo E., Million M., Edouard S., Mege J. L., Maurin M., Raoult D.
Source
Clinical Microbiology Reviews, 2017,
30 (1), p. 115-190 ISSN 0893-8512
Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
;
Biotechnologies [084]
Description Géographique
MONDE ; MALI ; BURKINA FASO ; NIGERIA ; CENTRAFRIQUE ; TCHAD ; EGYPTE ; NAMIBIE ; ALGERIE ; SENEGAL ; PAYS BAS ; GUYANE FRANCAISE
Localisation
Fonds IRD [F B010069286]
Identifiant IRD
fdi:010069286
