@article{fdi:010069279,
  title = {{S}tructure-guided identification of a family of dual receptor-binding {P}f{EMP}1 that is associated with cerebral malaria},
  author = {{L}ennartz, {F}. and {A}dams, {Y}. and {B}engtsson, {A}. and {O}lsen, {R}. {W}. and {T}urner, {L}. and {T}uikue {N}dam, {N}icaise and {E}cklu-{M}ensah, {G}. and {M}oussiliou, {A}. and {O}fori, {M}. {F}. and {G}amain, {B}. and {L}usingu, {J}. {P}. and {P}etersen, {J}. {E}. {V}. and {W}ang, {C}. {W}. and {N}unes-{S}ilva, {S}. and {J}espersen, {J}. {S}. and {L}au, {C}. {K}. {Y}. and {T}heander, {T}. {G}. and {L}avstsen, {T}. and {H}viid, {L}. and {H}iggins, {M}. {K}. and {J}ensen, {A}. {T}. {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}erebral malaria is a deadly outcome of infection by {P}lasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. {T}hese erythrocytes display parasite proteins of the {P}f{EMP}1 family that bind various endothelial receptors. {D}espite the importance of cerebral malaria, a binding phenotype linked to its symptoms has not been identified. {H}ere, we used structural biology to determine how a group of {P}f{EMP}1 proteins interacts with intercellular adhesion molecule 1 ({ICAM}-1), allowing us to predict binders from a specific sequence motif alone. {A}nalysis of multiple {P}lasmodium falciparum genomes showed that {ICAM}-1-binding {P}f{EMP}1s also interact with endothelial protein {C} receptor ({EPCR}), allowing infected erythrocytes to synergistically bind both receptors. {E}xpression of these {P}f{EMP}1s, predicted to bind both {ICAM}-1 and {EPCR}, is associated with increased risk of developing cerebral malaria. {T}his study therefore reveals an important {P}f{EMP}1-binding phenotype that could be targeted as part of a strategy to prevent cerebral malaria.},
  keywords = {},
  booktitle = {},
  journal = {{C}ell {H}ost and {M}icrobe},
  volume = {21},
  numero = {3},
  pages = {403--414},
  ISSN = {1931-3128},
  year = {2017},
  DOI = {10.1016/j.chom.2017.02.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010069279},
}