Roche Benjamin, Rougeron V., Quintana-Murci L., Renaud F., Abbate J. L., Prugnolle Franck. (2017). Might interspecific interactions between pathogens drive host evolution ? The case of Plasmodium species and Duffy-negativity in human populations. Trends in Parasitology, 33 (1), p. 21-29. ISSN 1471-4922.
Titre du document
Might interspecific interactions between pathogens drive host evolution ? The case of Plasmodium species and Duffy-negativity in human populations
Trends in Parasitology, 2017,
33 (1), p. 21-29 ISSN 1471-4922
Malarial infections have long been recognized as a driver of human evolution, as demonstrated by the influence of Plasmodium falciparum on sickle-cell anemia persistence. Duffy-negativity is another blood disorder thought to have been selected because it confers nearly complete resistance against Plasmodium vivax infection. Recent evidence suggests that the benefits of being Duffy negative cannot be expected to play a strong selective pressure on humans, whereas its costs cannot be considered as negligible. Here, we suggest that the cross-talk between P. falciparum and P. vivax in coinfected children could represent the most parsimonious explanation of the frequency of Duffy-negativity. We discuss how this new hypothesis could be tested and call for a reconsideration of the evolution of the Duffy-negative group.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde animal [080]
