@article{fdi:010068919,
  title = {{C}arcinogenic risk of emerging persistent organic pollutant perfluorooctane sulfonate ({PFOS}) : a proposal of classification},
  author = {{A}rrieta-{C}ortes, {R}. and {F}arias, {P}. and {H}oyo-{V}adillo, {C}. and {K}leiche {D}ray, {M}ina},
  editor = {},
  language = {{ENG}},
  abstract = {{P}erfluoroalkyls are stable synthetic chemicals, able to repel oils, fats and water. {T}hese compounds have been used in the manufacturing of products such as {T}eflon, lubricants, paints, fire-fighting foams, coatings for pans, carpets, clothes, and paperboard for packaging, among others. {I}t is believed that populations are exposed constantly to them. {I}ts regulation in the world is under development and several controversies are in the course of litigation. {O}ne occupational study shows bladder cancer risk. {T}his paper intends to review scientific information on the most critical perfluoroalkyl compound and proposes a procedure to get a cancer-risk categorization which {PFOS} can cause to populations. {M}ethods: {A}s a guiding axis, we used the {IARC} process for developing monographs of carcinogenic risks. {W}e used the {SIGN} guides for evaluating the quality of studies in human populations; and finally, we used the {S}quire method for evaluating studies in laboratory animals. {I}nadequate evidence of carcinogenicity was found in human studies mainly due to chance, threshold effect and confounders. {I}n experimental animal studies, inadequate evidence of carcinogenicity was found in view of the number of affected species, different types of neoplasms, dose-response relationship and genotoxicity found in in-vivo and in-vitro studies. {I}n this proposal, we concluded that cancer risk for {PFOS}, according to the {IARC} method, is not classifiable as carcinogenic to humans (group 3).},
  keywords = {{PFC}s ; {PFOS} ; {P}erfluorooctane sulfonate ; {C}arcinogenic risk ; {IARC} ; {G}enotoxicity ; {R}isk assessment ; {C}ancer ; {MEXIQUE}},
  booktitle = {},
  journal = {{R}egulatory {T}oxicology and {P}harmacology},
  volume = {83},
  numero = {},
  pages = {66--80},
  ISSN = {0273-2300},
  year = {2017},
  DOI = {10.1016/j.yrtph.2016.11.021},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068919},
}