@article{fdi:010068860,
  title = {{V}iral factors in influenza pandemic risk assessment},
  author = {{L}ipsitch, {M}. and {B}arclay, {W}. and {R}aman, {R}. and {R}ussell, {C}. {J}. and {B}elser, {J}. {A}. and {C}obey, {S}. and {K}asson, {P}. {M}. and {L}loyd-{S}mith, {J}. {O}. and {M}aurer-{S}troh, {S}. and {R}iley, {S}. and {B}eauchemin, {C}. {A}. {A}. and {B}edford, {T}. and {F}riedrich, {T}. {C}. and {H}andel, {A}. and {H}erfst, {S}. and {M}urcia, {P}. {R}. and {R}oche, {B}enjamin and {W}ilke, {C}. {O}. and {R}ussell, {C}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he threat of an influenza {A} virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. {T}o date, no pandemic emergence of a new influenza strain has been preceded by detection of a closely related precursor in an animal or human. {N}onetheless, influenza surveillance efforts are expanding, prompting a need for tools to assess the pandemic risk posed by a detected virus. {T}he goal would be to use genetic sequence and/or biological assays of viral traits to identify those non-human influenza viruses with the greatest risk of evolving into pandemic threats, and/or to understand drivers of such evolution, to prioritize pandemic prevention or response measures. {W}e describe such efforts, identify progress and ongoing challenges, and discuss three specific traits of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin p{H} of activation, and polymerase complex efficiency) that contribute to pandemic risk.},
  keywords = {},
  booktitle = {},
  journal = {{E}life},
  volume = {5},
  numero = {},
  pages = {e18491 [38 p.]},
  ISSN = {2050-084{X}},
  year = {2016},
  DOI = {10.7554/e{L}ife.18491},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068860},
}