@article{fdi:010068852,
  title = {{D}ifferential effects of azithromycin, doxycycline, and cotrimoxazole in ingested blood on the vectorial capacity of malaria mosquitoes},
  author = {{G}endrin, {M}. and {Y}erbanga, {R}. {S}. and {O}u{\'e}draogo, {J}. {B}. and {L}ef{\`e}vre, {T}hierry and {C}ohuet, {A}nna and {C}hristophides, {G}. {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {T}he gut microbiota of malaria vector mosquitoes grows after a blood meal and limits {P}lasmodium infection. {W}e previously showed that penicillin and streptomycin in the ingested blood affect bacterial growth and positively impact mosquito survival and permissiveness to {P}lasmodium. {I}n this study, we examine the effects of doxycycline, azithromycin, and co-trimoxazole. {A}ll 3 antibiotics are used in mass drug administration programs and have antimicrobial activities against bacteria and various stages of malaria parasites. {M}ethods. {T}he effects of blood meal supplementation with antibiotics on the mosquito microbiota, lifespan, and permissiveness to {P}lasmodium falciparum were assessed. {R}esults. {I}ngestion of any of the 3 antibiotics significantly affected the mosquito microbiota. {A}zithromycin decreased {P} falciparum infection load and mosquito lifespan, whereas at high concentrations, doxycycline increased {P} falciparum infection load. {C}o-trimoxazole negatively impacted infection intensity but had no reproducible effect on mosquito lifespan. {C}onclusions. {O}ur data suggest that the overall effect of antibiotic treatment on parameters critical for mosquito vectorial capacity is drug specific. {T}he negative effect of azithromycin on malaria transmission is consistent with current efforts for disease elimination, whereas additional, larger scale investigations are required before conclusions can be drawn about doxycycline.},
  keywords = {{A}nopheles ; antibiotics ; azithromycin ; microbiota ; {P}lasmodium falciparum ; {CAMEROUN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {3},
  numero = {2},
  pages = {[8 ]},
  ISSN = {2328-8957},
  year = {2016},
  DOI = {10.1093/ofid/ofw074},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068852},
}