@article{fdi:010068827,
  title = {{U}sefulness of a biomarker to identify placental dysfunction in the context of malaria},
  author = {{G}ueneuc, {A}. and {D}eloron, {P}hilippe and {B}ertin, {G}wladys},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n most tropical areas, pregnant women are at increased risk of malaria, as a consequence of the massive sequestration of parasitized red blood cells in the placenta. {T}he placenta plays a key role in embryonic and fetal development as well as in maternal-fetal exchanges, and pregnancy-associated malaria may alter selected placenta functions that lead to stillbirth and low birth weight. {A}lthough there are several tools (blood smear examination, {RDT}, {PCR}) to diagnose malaria infection during pregnancy, there is currently no test to assess placenta dysfunction in the framework of pregnancy-associated malaria. {P}regnancy-associated malaria shares many features with preeclampsia, an extensively studied disease. {V}arious biomarkers associated with placental dysfunction have been identified as associated with preeclampsia. {S}everal of these are inflammatory markers that lack of specificity. {A} few seem more specific of placenta dysfunction, including s-endoglin and s{F}lt1, increased in the peripheral blood during preeclampsia. {T}he predictive value of these biomarkers should be studied in the context of pregnancy-associated malaria to evaluate their usefulness in identifying placental dysfunction during malaria. {T}hese biomarkers should be considered to improve the diagnosis of placental dysfunction during malaria and pregnant women monitoring.},
  keywords = {{B}iomarker ; {P}regnancy malaria ; {P}reeclampsia ; {AFRIQUE}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {16},
  numero = {},
  pages = {art. 11 [7 p.]},
  ISSN = {1475-2875},
  year = {2017},
  DOI = {10.1186/s12936-016-1664-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068827},
}