@article{fdi:010068809,
  title = {{P}hylodynamics of the major {HIV}-1 {CRF}02_{AG} {A}frican lineages and its global dissemination},
  author = {{M}ir, {D}. and {J}ung, {M}. and {D}elatorre, {E}. and {V}idal, {N}icole and {P}eeters, {M}artine and {B}ello, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {HIV}-1 {CRF}02_{AG} clade is the most prevalent {HIV} variant in {W}est and {W}est-{C}entral {A}frica and its detection outside {A}frica is increasingly common. {L}ittle is known, however, about the number and phylodynamics of major {CRF}02_{AG} lineages circulating worldwide. {T}o this end, a total of 3170 {HIV}-1 {CRF}02_{AG}-like pol sequences isolated around the world, over a period of 25 years (1989 to 2013), were analyzed using {M}aximum {L}ikelihood and {B}ayesian coalescent-based methods. {O}ur results suggest that most of the current {CRF}02_{AG} diversity comes from the dissemination of a few founder strains out of {C}entral {A}frica into {W}est {A}frica and {C}ameroon between the late 1960s and the middle 1980s. {T}he {CRF}02_{AG} strain introduced into {W}est {A}frica established a large regional epidemic with low phylogeographic structure. {T}his strain was also successfully disseminated out of the {W}est {A}frican region and originated at least three large secondary outbreaks in {C}ameroon at around the late 1970s, in the former {S}oviet {U}nion ({FSU}) countries at around the late 1990s, and in {B}ulgaria/{G}ermany at around the early 2000s. {T}he {CRF}02_{AG} {A}frican lineages introduced into {C}ameroon remained mostly restricted to this country and its neighbors. {D}emographic reconstructions indicate that major {CRF}02_{AG} clades circulating in {A}frica exhibited a decline in growth rate since the middle 1980s/1990s, whereas {CRF}02_{AG} clades in {E}urope and the {FSU} countries continue to grow exponentially until the middle to late 2000s. {S}ubstantial differences in the median estimated growth rate of the same {CRF}02_{AG} clade circulating in different regions (0.63-2.00 year(-1)), and of different {CRF}02_{AG} clades circulating in the same country (0.41-0.75 year(-1)) were observed. {T}hus, the cause of the epidemic outcome of the different {HIV}-1 {CRF}02_{AG} lineages is probably multifactorial.},
  keywords = {{HIV}-1 ; {CRF}02_{AG} ; {A}frica ; {W}orldwide ; {P}hylodynamics ; {AFRIQUE}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {46},
  numero = {},
  pages = {190--199},
  ISSN = {1567-1348},
  year = {2016},
  DOI = {10.1016/j.meegid.2016.05.017},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068809},
}