@article{fdi:010068795,
  title = {{H}ydrogen production by the hyperthermophilic bacterium {T}hermotoga maritima {P}art {II} : modeling and experimental approaches for hydrogen production},
  author = {{A}uria, {R}ichard and {B}oileau, {C}{\'e}line and {D}avidson, {S}ylvain and {C}asalot, {L}aurence and {C}hristen, {P}ierre and {L}iebgott, {P}. {P}. and {C}ombet-{B}lanc, {Y}annick},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}hermotoga maritima is a hyperthermophilic bacterium known to produce hydrogen from a large variety of substrates. {T}he aim of the present study is to propose a mathematical model incorporating kinetics of growth, consumption of substrates, product formations, and inhibition by hydrogen in order to predict hydrogen production depending on defined culture conditions. {R}esults: {O}ur mathematical model, incorporating data concerning growth, substrates, and products, was developed to predict hydrogen production from batch fermentations of the hyperthermophilic bacterium, {T}. maritima. {I}t includes the inhibition by hydrogen and the liquid-to-gas mass transfer of {H}-2, {CO}2, and {H}2{S}. {M}ost kinetic parameters of the model were obtained from batch experiments without any fitting. {T}he mathematical model is adequate for glucose, yeast extract, and thiosulfate concentrations ranging from 2.5 to 20 mmol/{L}, 0.2-0.5 g/{L}, or 0.01-0.06 mmol/{L}, respectively, corresponding to one of these compounds being the growth-limiting factor of {T}. maritima. {W}hen glucose, yeast extract, and thiosulfate concentrations are all higher than these ranges, the model overestimates all the variables. {I}n the window of the model validity, predictions of the model show that the combination of both variables (increase in limiting factor concentration and in inlet gas stream) leads up to a twofold increase of the maximum {H}-2-specific productivity with the lowest inhibition. {C}onclusions: {A} mathematical model predicting {H}-2 production in {T}. maritima was successfully designed and confirmed in this study. {H}owever, it shows the limit of validity of such mathematical models. {T}heir limit of applicability must take into account the range of validity in which the parameters were established.},
  keywords = {{T}hermotoga maritima ; {H}yperthermophile ; {H}ydrogen ; {M}odeling ; {I}nhibition},
  booktitle = {},
  journal = {{B}iotechnology for {B}iofuels},
  volume = {9},
  numero = {},
  pages = {art. 268 [14 p.]},
  ISSN = {1754-6834},
  year = {2016},
  DOI = {10.1186/s13068-016-0681-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068795},
}