@article{fdi:010068717,
  title = {{C}loning, expression, molecular characterization and preliminary studies on immunomodulating properties of recombinant {T}rypanosoma congolense calreticulin},
  author = {{B}ossard, {G}. and {G}r{\'e}baut, {P}ascal and {T}hevenon, {S}. and {S}eveno, {M}. and {B}erthier, {D}. and {H}olzmuller, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}rypanosomes are bloodstream protozoan parasites, which are pathogens of veterinary and medical importance. {S}everal mammalian species, including humans, can be infected by different species of the genus {T}rypanosoma ({T}. congolense, {T}. evansi, {T}. brucei, {T}. vivax) exhibiting more or less virulent and pathogenic phenotypes. {A} previous screening of the excreted-secreted proteins of {T}. congolense demonstrated an overexpression of several proteins correlated with the virulence and pathogenicity of the strain. {O}f these proteins, calreticulin ({CRT}) has shown differential expression between two {T}. congolense strains with opposite infectious behavior and has been selected as a target molecule based on its immune potential functions in parasitic diseases. {I}n this study, we set out to determine the role of {T}. congolense calreticulin as an immune target. {I}mmunization of mice with recombinant {T}. congolense calreticulin induced antibody production, which was associated with delayed parasitemia and increased survival of the challenged animal. {T}hese results strongly suggest that some excreted-secreted proteins of {T}. congolense are a worthwhile target candidate to interfere with the infectious process.},
  keywords = {{A}nimal {A}frican {T}rypanosomosis ; {C}alreticulin ; {T}rypanosoma congolense ; {A}ntibodies ; {I}mmunomodulation},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {45},
  numero = {},
  pages = {320--331},
  ISSN = {1567-1348},
  year = {2016},
  DOI = {10.1016/j.meegid.2016.09.020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068717},
}