@article{fdi:010068698,
  title = {{E}ctopic activation of the rice {NLR} heteropair {RGA}4/{RGA}5 confers resistance to bacterial blight and bacterial leaf streak diseases},
  author = {{H}utin, {M}. and {C}esari, {S}. and {C}halvon, {V}. and {M}ichel, {C}. and {T}ran, {T}. {T}. and {B}och, {J}. and {K}oebnik, {R}alf and {S}zurek, {B}oris and {K}roj, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}acterial blight ({BB}) and bacterial leaf streak ({BLS}) are important diseases in {O}ryza sativa caused by {X}anthomonas oryzae pv. oryzae ({X}oo) and {X}anthomonas oryzae pv. oryzicola ({X}oc), respectively. {I}n both bacteria, transcription activator-like ({TAL}) effectors are major virulence determinants that act by transactivating host genes downstream of effector-binding elements ({EBE}s) bound in a sequence-specific manner. {R}esistance to {X}oo is mostly related to the action of {TAL} effectors, either by polymorphisms that prevent the induction of susceptibility ({S}) genes or by executor ({R}) genes with {EBE}s embedded in their promoter, and that induce cell death and resistance. {F}or {X}oc, no resistance sources are known in rice. {H}ere, we investigated whether the recognition of effectors by nucleotide binding and leucine-rich repeat domain immune receptors ({NLR}s), the most widespread resistance mechanism in plants, is also able to stop {BB} and {BLS}. {I}n one instance, transgenic rice lines harboring the {AVR}1-{CO}39 effector gene from the rice blast fungus {M}agnaporthe oryzae, under the control of an inducible promoter, were challenged with transgenic {X}oo and {X}oc strains carrying a {TAL} effector designed to transactivate the inducible promoter. {T}his induced {AVR}1-{CO}39 expression and triggered {BB} and {BLS} resistance when the corresponding {P}i-{CO}39 resistance locus was present. {I}n a second example, the transactivation of an auto-active {NLR} by {X}oo-delivered designer {TAL} effectors resulted in {BB} resistance, demonstrating that {NLR}-triggered immune responses efficiently control {X}oo. {T}his forms the foundation for future {BB} and {BLS} disease control strategies, whereupon endogenous {TAL} effectors will target synthetic promoter regions of {A}vr or {NLR} executor genes.},
  keywords = {},
  booktitle = {},
  journal = {{P}lant {J}ournal},
  volume = {88},
  numero = {1},
  pages = {43--55},
  ISSN = {0960-7412},
  year = {2016},
  DOI = {10.1111/tpj.13231},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068698},
}