%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Leroi, Charline
%A Adam, P.
%A Khamduang, W.
%A Kawilapat, S.
%A Ngo-Giang-Huong, Nicole
%A Ongwandee, S.
%A Jiamsiri, S.
%A Jourdain, Gonzague
%T Prevalence of chronic hepatitis B virus infection in Thailand : a systematic review and meta-analysis
%D 2016
%L fdi:010068695
%G ENG
%J International Journal of Infectious Diseases
%@ 1201-9712
%K Chronic hepatitis B ; Hepatitis B surface antigen ; Meta-analysis ; Prevalence ; Thailand
%K THAILANDE
%M ISI:000388326700010
%P 36-43
%R 10.1016/j.ijid.2016.08.017
%U https://www.documentation.ird.fr/hor/fdi:010068695
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers16-12/010068695.pdf
%V 51
%W Horizon (IRD)
%X Objective: To estimate the number of people living in Thailand with chronic hepatitis B (CHB), a major cause of liver cirrhosis and cancer, in view of the implementation of programs to prevent CHB complications. Methods: Using PubMed/Medline and ScienceDirect, all studies reporting hepatitis B surface antigen (HBsAg) seroprevalence estimates conducted in Thailand and published between 1975 and 2015 were reviewed systematically. Pooled prevalence estimates and their 95% confidence intervals (CIs) were calculated, and potential sources of heterogeneity investigated. Results: A high heterogeneity was observed between prevalence estimates. There was a significant decrease in the 150 estimates of HBsAg prevalence with more recent decades of birth (p < 0.001), even before the implementation of the national universal immunization program in 1992. When restricted to the general population, the pooled prevalence estimate was 5.1% (95% CI 4.3-6.0%), which would translate to an estimated number of individuals with CHB living in Thailand in 2015 as high as three million. Conclusions: The high burden of CHB in Asian countries is a major challenge for the incorporation of national programs to prevent CHB complications within health care systems.
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