Gineau Laure, Courtin David, Camara M., Ilboudo H., Jamonneau Vincent, Dias F. C., Tokplonou L., Milet Jacqueline, Mendona P. B., Castelli E. C., Camara O., Favier B., Rouas-Freiss N., Moreau P., Donadi E. A., Bucheton Bruno, Sabbagh A., Garcia André. (2016). Human leukocyte antigen-G : a promising prognostic marker of disease progression to improve the control of human African trypanosomiasis. Clinical Infectious Diseases, 63 (9), p. 1189-1197. ISSN 1058-4838.
Titre du document
Human leukocyte antigen-G : a promising prognostic marker of disease progression to improve the control of human African trypanosomiasis
Année de publication
2016
Auteurs
Gineau Laure, Courtin David, Camara M., Ilboudo H., Jamonneau Vincent, Dias F. C., Tokplonou L., Milet Jacqueline, Mendona P. B., Castelli E. C., Camara O., Favier B., Rouas-Freiss N., Moreau P., Donadi E. A., Bucheton Bruno, Sabbagh A., Garcia André
Source
Clinical Infectious Diseases, 2016,
63 (9), p. 1189-1197 ISSN 1058-4838
Background. Human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense can be diagnosed in the early hemolymphatic stage (stage 1 [S1]) or meningoencephalitic stage (stage 2 [S2]). Importantly, individuals harbouring high and specific antibody responses to Tbg antigens but negative parasitology are also diagnosed in the field (seropositive [SERO]). Whereas some develop the disease in the months following their initial diagnosis (SERO/HAT), others remain parasitologically negative for long periods (SERO) and are apparently able to control infection. Human leucocyte antigen (HLA)-G, an immunosuppressive molecule, could play a critical role in this variability of progression between infection and disease. Methods. Soluble HLA-G (sHLA-G) was measured in plasma for patients in the SERO (n = 65), SERO/HAT (n = 14), or HAT (n = 268) group and in cerebrospinal fluid for patients in S1 (n = 55), early S2 (n = 93), or late S2 (n = 110). Associations between these different statuses and the soluble level or genetic polymorphisms of HLA-G were explored. Results. Plasma sHLA-G levels were significantly higher in HAT (P = 6 x 10(-7)) and SERO/HAT (P = .007) than SERO patients. No difference was observed between the SERO/HAT and HAT groups. Within the HAT group, specific haplotypes (HG010102 and HG0103) displayed increased frequencies in S1 (P = .013) and late S2 (P = .036), respectively. Conclusions. These results strongly suggest the involvement of HLA-G in HAT disease progression. Importantly, high plasma sHLA-G levels in SERO patients could be predictive of subsequent disease development and could represent a serological marker to help guide therapeutic decision making. Further studies are necessary to assess the predictive nature of HLA-G and to estimate both sensitivity and specificity.
Plan de classement
Santé : généralités [050]
;
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
GUINEE
Localisation
Fonds IRD [F B010068692]
Identifiant IRD
fdi:010068692
