@article{fdi:010068665,
  title = {{I}ron and malaria : a dangerous liaison ?},
  author = {{M}oya-{A}lvarez, {V}. and {B}odeau-{L}ivinec, {F}. and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria increases the burden of anemia in low-income countries, where, according to 2012 data from the {W}orld {H}ealth {O}rganization, 40% of children are anemic. {M}oreover, iron is a cofactor for {P}lasmodium falciparum development, raising fears that iron supplementation might be harmful in patients with {P}. falciparum infection. {T}he primary objective of this narrative review is to describe current knowledge on the iron-malaria association, including recent findings and substantive qualitative results. {B}etween 2012 and 2016 the {MEDLINE} database was searched for literature published about malaria and iron levels. {O}bservational studies reported some protection of iron supplementation against malaria among iron-deficient children, while older clinical trials reported increased susceptibility to malaria among iron-supplemented children. {H}owever, iron supplements were not significantly associated with increased malaria risk in recent clinical trials or in a 2016 {C}ochrane review. {E}vidence of an iron-malaria association is limited by the following factors: the protective effect of control interventions, the limited follow-up of children, and the lack of homogenous iron indicators. {T}he effects of previous health status and possible thresholds in iron levels should be investigated using a gold-standard combination of iron markers. {M}oreover, the benefits of iron supplementation require further evaluation.},
  keywords = {anemia ; iron ; iron indicators ; iron supplements ; malaria ; {AFRIQUE} {SUBSAHARIENNE} ; {TANZANIE} ; {KENYA} ; {GHANA}},
  booktitle = {},
  journal = {{N}utrition {R}eviews},
  volume = {74},
  numero = {10},
  pages = {612--623},
  ISSN = {0029-6643},
  year = {2016},
  DOI = {10.1093/nutrit/nuw021},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068665},
}