%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Stucki, D.
%A Brites, D.
%A Jeljeli, L.
%A Coscolla, M.
%A Liu, Q.
%A Trauner, A.
%A Fenner, L.
%A Rutaihwa, L.
%A Borrell, S.
%A Luo, T.
%A Gao, Q.
%A Kato-Maeda, M.
%A Ballif, M.
%A Egger, M.
%A Macedo, R.
%A Mardassi, H.
%A Moreno, M.
%A Tudo Vilanova, G.
%A Fyfe, J.
%A Globan, M.
%A Thomas, J.
%A Jamieson, F.
%A Guthrie, J.L.
%A Asante-Poku, A.
%A Yeboah-Manu, D.
%A Wampande, E.
%A Ssengooba, W.
%A Moses Joloba, M.
%A Boom, W.H.
%A Basu, I.
%A Bower, J.
%A Saraiva, M.
%A Vasconcellos, S.E.G.
%A Suffys, P.
%A Koch, A.
%A Wilkinson, R.
%A Gail-Bekker, L.
%A Malla, B.
%A Ley, S.D.
%A Beck, H.P.
%A Jong, B.C. de
%A Toit, K.
%A Sanchez-Padilla, E.
%A Bonnet, Maryline
%A et. al.
%T Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
%D 2016
%L fdi:010068605
%G ENG
%J Nature Genetics
%@ 1061-4036
%K MONDE
%M ISI:000389011100014
%N 12
%P 1535-1543
%R 10.1038/ng.3704
%U https://www.documentation.ird.fr/hor/fdi:010068605
%V 48
%W Horizon (IRD)
%X Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
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