@article{fdi:010068428,
  title = {{A}kkermansia muciniphila and improved metabolic health during a dietary intervention in obesity : relationship with gut microbiome richness and ecology [plus {S}upplementary data]},
  author = {{D}ao, {M}.{C}. and {E}verard, {A}. and {A}ron-{W}isnewsky, {J}. and {S}okolovska, {N}. and {P}rifti, {E}. and {V}erger, {E}.{O}. and {K}ayser, {B}.{D}. and {L}evenez, {F}. and {C}hilloux, {J}. and {H}oyles, {L}. and {D}umas, {M}.{E}. and {R}izkalla, {S}.{W}. and {D}ore, {J}. and {C}ani, {P}.{D}. and {C}lement, {K}. and {MICRO}-{O}bes {C}onsortium and {L}e {M}ouha{\¨e}r, {S}. and {C}otillard, {A}. and {K}ennedy, {S}.{P}. and {P}ons, {N}. and {L}e {C}hatelier, {E}. and {A}lmeida, {M}. and {Q}uinquis, {B}. and {G}alleron, {N}. and {B}atto, {J}.{M}. and {R}enault, {P}. and {Z}ucker, {J}ean-{D}aniel and {D}usko {E}hrlich, {S}. and {B}lotti{\`e}re, {H}. and {L}eclerc, {M}. and {J}uste, {C}. and {D}e {W}outers, {T}. and {L}epage, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective. {I}ndividuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. {A}bundance of {A}kkermansia muciniphila, a mucin-degrading bacterium, has been inversely associated with body fat mass and glucose intolerance in mice, but more evidence is needed in humans. {T}he impact of diet and weight loss on this bacterial species is unknown. {O}ur objective was to evaluate the association between faecal {A}. muciniphila abundance, faecal microbiome gene richness, diet, host characteristics, and their changes after calorie restriction ({CR}). {D}esign. {T}he intervention consisted of a 6-week {CR} period followed by a 6-week weight stabilisation diet in overweight and obese adults ({N}=49, including 41 women). {F}aecal {A}. muciniphila abundance, faecal microbial gene richness, diet and bioclinical parameters were measured at baseline and after {CR} and weight stabilisation. {R}esults. {A}t baseline {A}. muciniphila was inversely related to fasting glucose, waist-to-hip ratio and subcutaneous adipocyte diameter. {S}ubjects with higher gene richness and {A}. muciniphila abundance exhibited the healthiest metabolic status, particularly in fasting plasma glucose, plasma triglycerides and body fat distribution. {I}ndividuals with higher baseline {A}. muciniphila displayed greater improvement in insulin sensitivity markers and other clinical parameters after {CR}. {T}hese participants also experienced a reduction in {A}. muciniphila abundance, but it remained significantly higher than in individuals with lower baseline abundance. {A}. muciniphila was associated with microbial species known to be related to health. {C}onclusions. {A}. muciniphila is associated with a healthier metabolic status and better clinical outcomes after {CR} in overweight/obese adults. {T}he interaction between gut microbiota ecology and {A}. muciniphila warrants further investigation.},
  keywords = {},
  booktitle = {},
  journal = {{G}ut},
  volume = {65},
  numero = {3},
  pages = {426--436 [+ 5 p.]},
  ISSN = {0017-5749},
  year = {2016},
  DOI = {10.1136/gutjnl-2014-308778},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068428},
}