%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Boufridi, A.
%A Petek, Sylvain
%A Evanno, L.
%A Beniddir, M.A.
%A Debitus, Cécile
%A Buisson, D.
%A Poupon, E.
%T Biotransformations versus chemical modifications : new cytotoxic analogs of marine sesquiterpene ilimaquinone [plus Supporting information]
%D 2016
%L fdi:010068406
%G ENG
%J Tetrahedron Letters
%@ 0040-4039
%M ISI:000386415300011
%N 44
%P 4922-4925 [+ 12 ]
%R 10.1016/j.tetlet.2016.09.075
%U https://www.documentation.ird.fr/hor/fdi:010068406
%> https://www.documentation.ird.fr/intranet/publi/depot/2016-10-19/010068406.pdf
%V 57
%W Horizon (IRD)
%X Highly biologically active marine sesquiterpene ilimaquinone was selected for chemical modifications. Its biotransformation was investigated using a combinatorial approach as an original way to screen different strains of microorganisms. Mucor circinelloides ATCC 8541 was able to structurally modify ilimaquinone into three different compounds. A stereospecific epoxidation was observed and compared to chemical epoxidation. A hydroxylation of the decalin ring was also observed as well as an unexpected substitution on the quinone ring by ethanolamine. Compounds were evaluated against several cell lines.
%$ 035 ; 034