@article{fdi:010068406, title = {{B}iotransformations versus chemical modifications : new cytotoxic analogs of marine sesquiterpene ilimaquinone [plus {S}upporting information]}, author = {{B}oufridi, {A}. and {P}etek, {S}ylvain and {E}vanno, {L}. and {B}eniddir, {M}.{A}. and {D}ebitus, {C}{\'e}cile and {B}uisson, {D}. and {P}oupon, {E}.}, editor = {}, language = {{ENG}}, abstract = {{H}ighly biologically active marine sesquiterpene ilimaquinone was selected for chemical modifications. {I}ts biotransformation was investigated using a combinatorial approach as an original way to screen different strains of microorganisms. {M}ucor circinelloides {ATCC} 8541 was able to structurally modify ilimaquinone into three different compounds. {A} stereospecific epoxidation was observed and compared to chemical epoxidation. {A} hydroxylation of the decalin ring was also observed as well as an unexpected substitution on the quinone ring by ethanolamine. {C}ompounds were evaluated against several cell lines.}, keywords = {}, booktitle = {}, journal = {{T}etrahedron {L}etters}, volume = {57}, numero = {44}, pages = {4922--4925 [+ 12 p.]}, ISSN = {0040-4039}, year = {2016}, DOI = {10.1016/j.tetlet.2016.09.075}, URL = {https://www.documentation.ird.fr/hor/fdi:010068406}, }