%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Turkova, A.
%A Chappell, E.
%A Chalermpantmetagul, S.
%A Della Negra, M.
%A Volokha, A.
%A Primak, N.
%A Solokha, S.
%A Rozenberg, V.
%A Kiselyova, G.
%A Yastrebova, E.
%A Miloenko, M.
%A Bashakatova, N.
%A Kanjanavanit, S.
%A Calvert, J.
%A Rojo, P.
%A Ansone, S.
%A Jourdain, Gonzague
%A Malyuta, R.
%A Goodall, R.
%A Judd, A.
%A Thorne, C.
%T Tuberculosis in HIV-infected children in Europe, Thailand and Brazil : paediatric TB-HIV EuroCoord study
%D 2016
%L fdi:010068375
%G ENG
%J International Journal of Tuberculosis and Lung Disease
%@ 1027-3719
%K HIV-TB coinfection ; children ; observational study
%K EUROPE ; THAILANDE ; BRESIL
%M ISI:000386986700007
%N 11
%P 1448-1456
%R 10.5588/ijtld.16.0067
%U https://www.documentation.ird.fr/hor/fdi:010068375
%> https://www.documentation.ird.fr/intranet/publi/2016/12/010068375.pdf
%V 20
%W Horizon (IRD)
%X SETTING: Centres participating in the Paediatric European Network for Treatment of AIDS (PENTA), including Thailand and Brazil. OBJECTIVE: To describe the incidence, presentation, treatment and treatment outcomes of tuberculosis (TB) in human immunodeficiency virus (HIV) infected children. DESIGN: Observational study of TB diagnosed in HIV infected children in 2011-2013. RESULTS: Of 4265 children aged <16 years, 127 (3%) were diagnosed with TB: 6 (5%) in Western Europe, 80 (63%) in Eastern Europe, 27 (21%) in Thailand and 14 (11%) in Brazil, with estimated TB incidence rates of respectively 239, 982, 1633 and 2551 per 100 000 person-years (py). The majority (94%) had acquired HIV perinatally. The median age at TB diagnosis was 6.8 years (interquartile range 3.0-11.5). Over half (52%) had advanced/severe World Health Organization stage immunodeficiency; 67 (53%) were not on antiretroviral therapy (ART) at TB diagnosis. Preventive antituberculosis treatment was given to 23% (n=23) of 102 children diagnosed with HIV before TB. Eleven children had unfavourable TB outcomes: 4 died, 5 did not complete treatment, 1 had recurrent TB and 1 had an unknown outcome. In univariable analysis, previous diagnosis of acquired immune-deficiency syndrome, not being virologically suppressed on ART at TB diagnosis and region (Brazil) were significantly associated with unfavourable TB outcomes. CONCLUSION: Most TB cases were from countries with high TB prevalence. The majority (91%) had favourable outcomes. Universal ART and TB prophylaxis may reduce missed opportunities for TB prevention.
%$ 052 ; 050 ; 084