@article{fdi:010068375,
  title = {{T}uberculosis in {HIV}-infected children in {E}urope, {T}hailand and {B}razil : paediatric {TB}-{HIV} {E}uro{C}oord study},
  author = {{T}urkova, {A}. and {C}happell, {E}. and {C}halermpantmetagul, {S}. and {D}ella {N}egra, {M}. and {V}olokha, {A}. and {P}rimak, {N}. and {S}olokha, {S}. and {R}ozenberg, {V}. and {K}iselyova, {G}. and {Y}astrebova, {E}. and {M}iloenko, {M}. and {B}ashakatova, {N}. and {K}anjanavanit, {S}. and {C}alvert, {J}. and {R}ojo, {P}. and {A}nsone, {S}. and {J}ourdain, {G}onzague and {M}alyuta, {R}. and {G}oodall, {R}. and {J}udd, {A}. and {T}horne, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{SETTING}: {C}entres participating in the {P}aediatric {E}uropean {N}etwork for {T}reatment of {AIDS} ({PENTA}), including {T}hailand and {B}razil. {OBJECTIVE}: {T}o describe the incidence, presentation, treatment and treatment outcomes of tuberculosis ({TB}) in human immunodeficiency virus ({HIV}) infected children. {DESIGN}: {O}bservational study of {TB} diagnosed in {HIV} infected children in 2011-2013. {RESULTS}: {O}f 4265 children aged <16 years, 127 (3%) were diagnosed with {TB}: 6 (5%) in {W}estern {E}urope, 80 (63%) in {E}astern {E}urope, 27 (21%) in {T}hailand and 14 (11%) in {B}razil, with estimated {TB} incidence rates of respectively 239, 982, 1633 and 2551 per 100 000 person-years (py). {T}he majority (94%) had acquired {HIV} perinatally. {T}he median age at {TB} diagnosis was 6.8 years (interquartile range 3.0-11.5). {O}ver half (52%) had advanced/severe {W}orld {H}ealth {O}rganization stage immunodeficiency; 67 (53%) were not on antiretroviral therapy ({ART}) at {TB} diagnosis. {P}reventive antituberculosis treatment was given to 23% (n=23) of 102 children diagnosed with {HIV} before {TB}. {E}leven children had unfavourable {TB} outcomes: 4 died, 5 did not complete treatment, 1 had recurrent {TB} and 1 had an unknown outcome. {I}n univariable analysis, previous diagnosis of acquired immune-deficiency syndrome, not being virologically suppressed on {ART} at {TB} diagnosis and region ({B}razil) were significantly associated with unfavourable {TB} outcomes. {CONCLUSION}: {M}ost {TB} cases were from countries with high {TB} prevalence. {T}he majority (91%) had favourable outcomes. {U}niversal {ART} and {TB} prophylaxis may reduce missed opportunities for {TB} prevention.},
  keywords = {{HIV}-{TB} coinfection ; children ; observational study ; {EUROPE} ; {THAILANDE} ; {BRESIL}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {T}uberculosis and {L}ung {D}isease},
  volume = {20},
  numero = {11},
  pages = {1448--1456},
  ISSN = {1027-3719},
  year = {2016},
  DOI = {10.5588/ijtld.16.0067},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068375},
}