@article{fdi:010068336,
  title = {{A}nti-infective assessment of {S}enecio smithioides ({A}steraceae) and isolation of 9-oxoeuryopsin, a furanoeremophilane-type sesquiterpene with antiplasmodial activity},
  author = {{M}ollinedo, {P}. and {V}ila, {J}. {L}. and {A}rando, {H}. and {S}auvain, {M}ichel and {D}eharo, {E}ric and {B}ravo, {J}. {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he search for anti-infective activity in the antipyretic plant {S}enecio smithioides was conducted. {P}etroleum ether ({PE}), dichloromethane ({CH}2{C}l2), ethyl acetate ({E}t{OA}c) and hydroethanolic (96% {E}t{OH}) extracts, and compounds 9-oxoeuryopsin (1), epoxydecompostin (2) and senecionine (3) were obtained from the aerial parts. {A}ll extracts and 1 were tested against chloroquine-resistant strain of {P}lasmodium falciparum (ref. chloroquine), {T}rypanosoma cruzi (ref. nifurtimox), {L}eishmania braziliensis, {L}eishmania amazonensis and {L}eishmania donovani (ref. pentamidine), {S}taphylococcus aureus and {E}scherichia coli (ref. gentamicin) and, {N}eurospora crassa and {C}andida albicans (ref. ketoconazole). {T}he {PE} extract exhibited the strongest in vitro activity against {P}lasmodium falciparum {IC}50<1.0g/m{L}. 1 was established as a potent antiplasmodial compound with an {IC}50=1.2g/m{L}, 5.2{M}. {O}ther antiparasitic activities were recorded for all extracts and 1. {A}ntibacterial and antifungal activity was negligible.},
  keywords = {{S}enecio smithioides ; {P}lasmodium falciparum ; furanoeremophilane-type ; sesquiterpene ; {A}steraceae ; structural elucidation},
  booktitle = {},
  journal = {{N}atural {P}roduct {R}esearch},
  volume = {30},
  numero = {22},
  pages = {2594--2597},
  ISSN = {1478-6419},
  year = {2016},
  DOI = {10.1080/14786419.2015.1115994},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068336},
}