@article{fdi:010068293,
  title = {{ZIKA} virus reveals broad tissue and cell tropism during the first trimester of pregnancy},
  author = {{E}l {C}osta, {H}. and {G}ouilly, {J}. and {M}ansuy, {J}. {M}. and {C}hen, {Q}. and {L}evy, {C}. and {C}artron, {G}. and {V}eas, {F}rancisco and {A}l-{D}accak, {R}. and {I}zopet, {J}. and {J}abrane-{F}errat, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he outbreak of the {Z}ika {V}irus ({ZIKV}) and its association with fetal abnormalities have raised worldwide concern. {H}owever, the cellular tropism and the mechanisms of {ZIKV} transmission to the fetus during early pregnancy are still largely unknown. {T}herefore, we ex vivo modeled the {ZIKV} transmission at the maternal-fetal interface using organ culture from first trimester pregnancy samples. {H}ere, we provide evidence that {ZIKV} strain circulating in {B}razil infects and damages tissue architecture of the maternal decidua basalis, the fetal placenta and umbilical cord. {W}e also show that {ZIKV} replicates differentially in a wide range of maternal and fetal cells, including decidual fibroblasts and macrophages, trophoblasts, {H}ofbauer cells as well as umbilical cord mesenchymal stem cells. {T}he striking cellular tropism of {ZIKV} and its cytopathic-induced tissue injury during the first trimester of pregnancy could provide an explanation for the irreversible congenital damages.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {6},
  numero = {},
  pages = {art. 35296 [9 p.]},
  ISSN = {2045-2322},
  year = {2016},
  DOI = {10.1038/srep35296},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068293},
}