@article{fdi:010068168,
  title = {{Z}oonotic trypanosomes in {S}outh {E}ast {A}sia : attempts to control {T}rypanosoma lewisi using human and animal trypanocidal drugs},
  author = {{D}esquesnes, {M}. and {Y}angtara, {S}. and {K}unphukhieo, {P}. and {J}ittapalapong, {S}. and {H}erder, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{B}eside typical human trypanosomes responsible of sleeping sickness in {A}frica and {C}hagas disease in {L}atin {A}merica, there is a growing number of reported atypical human infections due to {T}rypanosoma evansi, a livestock parasite, or {T}rypanosoma lewisi, a rat parasite, especially in {A}sia. {D}rugs available for the treatment of {T}. brucei ssp. in humans are obviously of choice for the control of {T}. evansi because it is derived from {T}. brucei. {H}owever, concerning {T}. lewisi, there is an urgent need to determine the efficacy of trypanocidal drugs for the treatment in humans. {I}n a recent study, pentamidine and fexinidazole were shown to have the best efficacy against one stock of {T}. lewisi in rats. {I}n the present study suramin, pentamidine, eflornitine, nifurtimox, benznidazole and fexinidazole, were evaluated at low and high doses, in single day administration to normal rats experimentally infected with a stock of {T}. lewisi recently isolated in {T}hailand. {B}ecause none of these treatments was efficient, a trial was made with the most promising trypanocide identified in a previous study, fexinidazole 100 mg/kg, in 5 daily administrations. {R}esults observed were unclear. {T}o confirm the efficacy of fexinidazole, a mixed infection protocol was set up in cyclophosphamide immunosuppressed rats. {A}nimals were infected successively by {T}. lewisi and {T}. evansi, and received 10 daily {PO} administrations of 200 mg/kg fexinidazole. {D}rastic effects were observed against {T}. evansi which was cleared from the rat's blood within 24 to 48 h; however, the treatment did not affect {T}. lewisi which remained in high number in the blood until the end of the experiment. {T}his mixed infection/treatment protocol clearly demonstrated the efficacy of fexinidazole against {T}. evansi and its inefficacy against {T}. lewisi. {S}ince animal trypanocides were also recently shown to be inefficient, other protocols as well as other {T}. lewisi stocks should be investigated in further studies.},
  keywords = {{T}rypanosoma lewisi ; {T}rypanocidals ; {F}exinidazole ; {T}rypanosoma evansi ; {E}fficacy ; {R}ats ; {S}uramin ; {P}entamidine ; {E}flornitine ; {N}ifurtimox ; {B}enznidazole ; {THAILANDE}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {44},
  numero = {},
  pages = {514--521},
  ISSN = {1567-1348},
  year = {2016},
  DOI = {10.1016/j.meegid.2016.07.041},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068168},
}