@article{fdi:010068159,
  title = {{A}ntibacterial activity of {L}itsea cubeba ({L}auraceae, {M}ay {C}hang) and its effects on the biological response of common carp {C}yprinus carpio challenged with {A}eromonas hydrophila},
  author = {{N}guyen, {H}. {V}. and {C}aruso, {D}omenico and {L}ebrun, {M}. and {N}guyen, {N}. {T}. and {T}rinh, {T}. {T}. and {M}eile, {J}. {C}. and {C}hu-{K}y, {S}. and {S}arter, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}ims: {T}he aims of this study were to characterize the antibacterial activity and the chemotype of {L}itsea cubeba leaf essential oil ({EO}) harvested in {N}orth {V}ietnam and to investigate the biological effects induced by the leaf powder on growth, nonspecific immunity and survival of common carp ({C}yprinus carpio) challenged with {A}eromonas hydrophila. {M}ethods and {R}esults: {T}he {EO} showed the prevalence of linalool (95%, n = 5). {I}t was bactericidal against the majority of tested strains, with minimum inhibitory concentrations ranging from 0.72 to 2.89 mg ml(-1) ({A}er. hydrophila, {E}dwarsiella tarda, {V}ibrio furnissii, {V}ibrio parahaemolyticus, {S}treptococcus garvieae, {E}scherichia coli, {S}almonella {T}yphimurium). {T}he fish was fed with 0 (control), 2, 4 and 8% leaf powder supplementation diets for 21 days. {N}onspecific immunity parameters (lysozyme, haemolytic and bactericidal activities of plasma) were assessed 21 days after feeding period and before the experimental infection. {W}eight gain, specific growth rate and feed conversion ratio were improved by supplementation of {L}. cubeba in a dose-related manner, and a significant difference appeared at the highest dose (8%) when compared to the control. {T}he increase in plasma lysozyme was significant for all the treated groups. {H}aemolysis activity was higher for the groups fed with 4 and 8% plant powder. {A}ntibacterial activity increased significantly for the 8% dose only. {C}onclusions: {L}itsea cubeba leaf powder increased nonspecific immunity of carps in dose-related manner. {A}fter infection with {A}er. hydrophila, survivals of fish fed with 4 and 8% {L}. cubeba doses were significantly higher than those fed with 2% dose and the control. {S}ignificance and {I}mpact of the {S}tudy: {A} range of 4-8% {L}. cubeba leaf powder supplementation diet (from specific linalool-rich chemotype) can be used in aquaculture to reduce antibiotic burden and impacts of diseases caused by {A}er. hydrophila.},
  keywords = {{A}eromonas hydrophila ; {C}yprinus carpio ; innate immune response ; {L}itsea cubeba ; natural antimicrobials ; {V}ietnam ; {VIET} {NAM}},
  booktitle = {},
  journal = {{J}ournal of {A}pplied {M}icrobiology},
  volume = {121},
  numero = {2},
  pages = {341--351},
  ISSN = {1364-5072},
  year = {2016},
  DOI = {10.1111/jam.13160},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068159},
}