@article{fdi:010068145,
  title = {{I}mmunoglobulin response to the low polymorphic {P}f113 antigen in children from {L}astoursville, {S}outh-{E}ast of {G}abon},
  author = {{I}mboumy-{L}imoukou, {R}. {K}. and {M}aghendi-{N}zondo, {S}. and {K}ouna, {C}. {L}. and {B}ounaadja, {L}. and {M}bang, {S}. and {B}iteghe, {J}. {C}. and {E}boumbou, {C}. and {P}rugnolle, {F}ranck and {F}lorent, {I}. and {L}ekana-{D}ouki, {J}. {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}f113 is a {P}. falciparum putatively {GPI}-anchoredprotein that has been so far localized at the surface of merozoites, suggesting it could interact with {RBC} surface during merozoite invasion. {P}revious studies conducted in {P}apua {N}ew {G}uinea and in {K}enya have revealed that this protein is recognized by natural antibodies in individuals living in malaria-endemic areas and is associated with protective immunity in malaria, further supporting the potential of {P}f113 for the development of anti-malaria vaccines. {H}owever, in {C}entral {A}frica, no study on the immunogenicity of this protein has been conducted. {H}ere, we report the characterization of the {P}f113 immune response in 103 children by {E}nzyme-{L}inked {I}mmunoabsorbent {A}ssay ({ELISA}), using a recombinant form of {P}f113 expressed in {E}scherichia coli, together with the study of the {P}f113 polymorphism, after amplification and sequencing of 40 field isolates. {D}ata showed that almost 51% of the studied individuals had positive antibody responses to the recombinant {P}f113 protein, and that {I}g{G} subclass response was dominated by {I}g{G}3 (84%) followed by {I}g{G}1 (50%). {S}urprisingly the prevalence of {I}g{G}4 was 92%. {I}n addition, gene analysis in field isolates from this region indicated that {P}f113 was not highly polymorphic, in particular regarding high-activity binding peptides ({HABP}s). {O}ur data reinforce the idea that {P}f113 may be considered for inclusion in multicomponent blood-stage vaccines.},
  keywords = {{P}f113 ; {I}mmunogenicity ; {I}mmunoglobulin ; {P}. falciparum ; {P}olymorphism ; {GABON}},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {163},
  numero = {},
  pages = {149--156},
  ISSN = {0001-706{X}},
  year = {2016},
  DOI = {10.1016/j.actatropica.2016.08.014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010068145},
}