%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Zebiri, I.
%A Haddad, Mohamed
%A Duca, L.
%A Harakat, D.
%A Cabanillas, B.
%A Paloque, L.
%A Scandolera, A.
%A Sauvain, Michel
%A Rengifo, E.
%A Voutquenne-Nazabadioko, L.
%T Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana
%D 2016
%L fdi:010068140
%G ENG
%J Phytochemistry
%@ 0031-9422
%K Dendrobangia boliviana ; Cardiopteridaceae ; Triterpenoid saponins ; Cytotoxic activity
%K PEROU ; AMAZONIE
%M ISI:000383302900026
%P 262-272
%R 10.1016/j.phytochem.2016.06.006
%U https://www.documentation.ird.fr/hor/fdi:010068140
%> https://www.documentation.ird.fr/intranet/publi/2016/10/010068140.pdf
%V 130
%W Horizon (IRD)
%X Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunumoside I and 3-O-beta-D-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR (H-1, C-13, DEPT) and 2D-NMR (H-1-H-1 COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 mu M, respectively.
%$ 076 ; 020