Zebiri I., Haddad Mohamed, Duca L., Harakat D., Cabanillas B., Paloque L., Scandolera A., Sauvain Michel, Rengifo E., Voutquenne-Nazabadioko L. (2016). Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana. Phytochemistry, 130, p. 262-272. ISSN 0031-9422.
Titre du document
Zebiriosides A-L, oleanane saponins from the roots of Dendrobangia boliviana
Année de publication
2016
Auteurs
Zebiri I., Haddad Mohamed, Duca L., Harakat D., Cabanillas B., Paloque L., Scandolera A., Sauvain Michel, Rengifo E., Voutquenne-Nazabadioko L.
Source
Phytochemistry, 2016,
130, p. 262-272 ISSN 0031-9422
Twelve oleanane saponins, zebiriosides A-L, were isolated from the roots of Dendrobangia boliviana Rusby, together with two known saponins, talunumoside I and 3-O-beta-D-glucuronopyranosyl serjanic acid. These saponins are glycosides of serjanic or phytolaccinic acid. Their structures were established on two basis: first, their spectral data, mainly HR-TOFESIMS, 1D-NMR (H-1, C-13, DEPT) and 2D-NMR (H-1-H-1 COSY, TOCSY, HSQC, HMBC, and ROESY), and second by comparison with literature data. These compounds were evaluated for their cytotoxic, antileishmanial and hemolytic activities. No antileishmanial or hemolytic activities were revealed, however zebirioside C and zebirioside I showed cytotoxicity against fibroblasts with IC50 of 6.4 and 5.6 mu M, respectively.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Sciences du monde végétal [076]
Description Géographique
PEROU ; AMAZONIE
Localisation
Fonds IRD [F B010068140]
Identifiant IRD
fdi:010068140
