@article{fdi:010067799,
  title = {{P}reclinical evaluation of three polyspecific antivenoms against the venom of {E}chis ocellatus : neutralization of toxic activities and antivenomics},
  author = {{C}alvete, {J}. {J}. and {A}rias, {A}. {S}. and {R}odriguez, {Y}. and {Q}uesada-{B}ernat, {S}. and {S}anchez, {L}. {V}. and {C}hippaux, {J}ean-{P}hilippe and {P}la, {D}. and {G}utierrez, {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}nakebite envenoming has a heavy burden in the public health in sub-{S}aharan {A}frica. {T}he viperid species {E}chis ocellatus (carpet viper or saw-scaled viper) is the medically most important snake in the savannahs of western sub-{S}aharan {A}frica. {S}everal antivenoms are being distributed and used in this region for the treatment of envenomings by {E}. ocellatus, but the preclinical efficacy of some of these antivenoms has not been assessed. {T}he present study evaluated the preclinical efficacy against {E}. ocellatus venom of three polyspecific antivenoms: (a) {S}nake {V}enom {A}ntiserum ({P}an {A}frica), manufactured by {P}remium {S}erums and {V}accines ({I}ndia); (b) {S}nake {V}enom {A}ntiserum ({A}frica), manufactured by {VINS} {B}ioproducts ({I}ndia); and (c) {A}ntivipmyn ({R}) {A}frica, manufactured by {I}nstitute {B}ioclon ({M}exico). {A}ntivenomics analysis revealed the ability of the three antivenoms to immunocapture the majority of components of the venoms of {E}. ocellatus from {C}ameroon, {N}igeria and {M}ali, although their maximal immunocapturing capability varied. {B}ioclon and {P}remium {S}erums antivenoms were effective in the neutralization of lethal, hemorrhagic and in vitro coagulant activities of the venom of {E}. ocellatus from {C}ameroon, albeit with different potencies. {VINS} antivenom neutralized hemorrhagic activity of this venom, but failed to neutralize lethality at the highest antivenom dose tested, and had a low neutralizing efficacy against in vitro coagulant effect.},
  keywords = {{A}frica ; {E}chis ocellatus venom ; {A}ntivenoms ; {N}eutralization ; {A}ntivenomics ; {L}ethality ; {AFRIQUE} {SUBSAHARIENNE} ; {MALI} ; {CAMEROUN} ; {NIGERIA}},
  booktitle = {},
  journal = {{T}oxicon},
  volume = {119},
  numero = {},
  pages = {280--288},
  ISSN = {0041-0101},
  year = {2016},
  DOI = {10.1016/j.toxicon.2016.06.022},
  URL = {https://www.documentation.ird.fr/hor/fdi:010067799},
}