@article{fdi:010067717,
  title = {{A} multi-scale model of the interplay between cell signalling and hormone transport in specifying the root meristem of {A}rabidopsis thaliana},
  author = {{M}uraro, {D}. and {L}arrieu, {A}. and {L}ucas, {M}ika{\¨e}l and {C}hopard, {J}. and {B}yrne, {H}. and {G}odin, {C}. and {K}ing, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he growth of the root of {A}rabidopsis thaliana is sustained by the meristem, a region of cell proliferation and differentiation which is located in the root apex and generates cells which move shootwards, expanding rapidly to cause root growth. {T}he balance between cell division and differentiation is maintained via a signalling network, primarily coordinated by the hormones auxin, cytokinin and gibberellin. {S}ince these hormones interact at different levels of spatial organisation, we develop a multi-scale computational model which enables us to study the interplay between these signalling networks and cell-cell communication during the specification of the root meristem. {W}e investigate the responses of our model to hormonal perturbations, validating the results of our simulations against experimental data. {O}ur simulations suggest that one or more additional components are needed to explain the observed expression patterns of a regulator of cytokinin signalling, {ARR}1, in roots not producing gibberellin. {B}y searching for novel network components, we identify two mutant lines that affect significantly both root length and meristem size, one of which also differentially expresses a central component of the interaction network ({SHY}2). {M}ore generally, our study demonstrates how a multi-scale investigation can provide valuable insight into the spatio-temporal dynamics of signalling networks in biological tissues.},
  keywords = {{G}ene networks ; {P}lant hormones ; {T}issue differentiation},
  booktitle = {},
  journal = {{J}ournal of {T}heoretical {B}iology},
  volume = {404},
  numero = {},
  pages = {182--205},
  ISSN = {0022-5193},
  year = {2016},
  DOI = {10.1016/j.jtbi.2016.04.036},
  URL = {https://www.documentation.ird.fr/hor/fdi:010067717},
}