@article{fdi:010067715,
  title = {{M}ycobacterium tuberculosis lineages and anti-tuberculosis drug resistance in reference hospitals across {V}iet {N}am},
  author = {{V}an {A}nh {T}hi {N}guyen, and {B}anuls, {A}nne-{L}aure and {T}hanh {H}oa {T}hi {T}ran, and {K}im {L}ien {T}hi {P}ham, and {T}hai {S}on {N}guyen, and {H}ung {V}an {N}guyen, and {N}goc {L}an {T}hi {N}guyen, and {N}am {L}ien {T}hi {N}guyen, and {D}uc {A}nh {D}ang, and {M}arks, {G}. {B}. and {C}hoisy, {M}arc},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {M}ycobacterium tuberculosis, the tuberculosis ({TB}) pathogen, despite a low level of genetic diversity, has revealed a high variety of biological and epidemiological characteristics linked to their lineages, such as transmissibility, fitness and propensity to acquire drug resistance. {T}his has important implications for the epidemiology of {TB}. {W}e conducted this first countrywide cross-sectional study to identify the prevalent {M}. tuberculosis lineages and to assess their epidemiological associations and their relation to drug resistance. {T}he study was conducted among isolates acquired in reference hospitals across {V}ietnam. {I}solates with drug susceptibility testing profiles were identified for their lineages by spoligotyping. {L}ogistic regression was used to investigate the association of {M}. tuberculosis lineages with location, age and sex of the patients and drug resistance levels. {R}esults: {R}esults showed that the most prevalent lineage was {B}eijing (55.4 %), followed by {EAI} (27.5 %), {T} (6.4 %), {LAM} (1.3 %), {H}aarlem (1 %) and {Z}ero type (0.3 %). {T}he proportion of {B}eijing isolates in the {N}orth (70.4 %) and the {S}outh (68 %) was higher than in the {C}entre (28 %) ({OR} = 1.7 [95 % {CI}: 1.4-2.0], p < 0.0001), whereas the proportion of {EAI} isolates in the {N}orth (7.1 %) and the {S}outh (17 %) was much lower compared with the {C}entre (59 %) ({OR} = 0.5 [95 % {CI}: 0.4-0.6], p < 0.0001). {O}verall, {B}eijing isolates were the most likely to be drug-resistant and {EAI} isolates were the least likely to be drug-resistant, except in the {S}outh of {V}ietnam where {EAI} is also highly drug-resistant. {T}he proportion of {B}eijing isolates was significantly higher (p < 0.01), and the proportion of {EAI} isolates was significantly lower (p < 0.05) in younger patients. {T}he proportion of drug-resistance was higher in isolates collected from male patients and from patients in the middle age groups. {C}onclusions: {T}he findings suggest ongoing replacement of {EAI} lineage, which is mainly more drug-susceptible with highly drug-resistant {B}eijing lineage in all studied regions of {V}ietnam. {M}ale patients of working ages should be the focus for better control to prevent the emergence of drug-resistant {TB}.},
  keywords = {{T}uberculosis ; {M}ycobacterium tuberculosis ; {L}ineage ; {D}rug resistance ; {R}eference hospital ; {V}ietnam ; {VIET} {NAM}},
  booktitle = {},
  journal = {{BMC} {M}icrobiology},
  volume = {16},
  numero = {},
  pages = {art. 167 [9 p.]},
  ISSN = {1471-2180},
  year = {2016},
  DOI = {10.1186/s12866-016-0784-6},
  URL = {https://www.documentation.ird.fr/hor/fdi:010067715},
}