Publications des scientifiques de l'IRD

Sirirungsi W., Khamduang W., Collins I. J., Pusamang A., Leechanachai P., Chaivooth S., Ngo-Giang-Huong Nicole, Samleerat T. (2016). Early infant HIV diagnosis and entry to HIV care cascade in Thailand : an observational study. Lancet HIV, 3 (6), p. E259-E265. ISSN 2352-3018.

Titre du document
Early infant HIV diagnosis and entry to HIV care cascade in Thailand : an observational study
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000378950100007
Auteurs
Sirirungsi W., Khamduang W., Collins I. J., Pusamang A., Leechanachai P., Chaivooth S., Ngo-Giang-Huong Nicole, Samleerat T.
Source
Lancet HIV, 2016, 3 (6), p. E259-E265 ISSN 2352-3018
Background Early infant diagnosis of HIV is crucial for timely initiation of antiretroviral therapy (ART) in infected children who are at high risk of mortality. Early infant diagnosis with dried blood spot testing was provided by the National AIDS Programme in Thailand from 2007. We report ART initiation and vital status in children with HIV after 7 years of rollout in Thailand. Methods Dried blood spot samples were collected from HIV-exposed children in hospitals in Thailand and mailed to the Faculty of Associated Medical Sciences, Chiang Mai University, where HIV DNA was assessed with real-time PCR to establish HIV infection. We linked data from children with an HIV infection to the National AIDS Programme database to ascertain ART and vital status. Findings Between April 5, 2007, and Oct 1, 2014, 16 046 dried blood spot samples were sent from 8859 children in 364 hospitals in Thailand. Median age at first dried blood spot test was 2.1 (IQR 1.8-2.5) months. Of 7174 (81%) children with two or more samples, 223 (3%) were HIV positive (including five unconfirmed). Of 1685 (19%) children with one sample, 70 (4%) were unconfirmed positive. Of 293 (3%) children who were HIV positive, 220 (75%) registered for HIV care and 170 (58%) initiated ART. Median age at ART initiation decreased from 14.2 months (IQR 10.2-25.6) in 2007 to 6.1 months (4.2-9.2) in 2013, and the number of children initiating ART aged younger than 1 year increased from five (33%) of 15 children initiating ART in 2007 to ten (83%) of 12 initiating ART in 2013. 15 (9%) of 170 children who initiated ART died and 16 (32%) of 50 who had no ART record died. Interpretation Early infant diagnosis with dried blood spot testing had high uptake in primary care settings. Further improvement of linkage to HIV care is needed to ensure timely treatment of all children with an HIV infection.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052] ; Santé : aspects socioculturels, économiques et politiques [056]
Description Géographique
THAILANDE
Localisation
Fonds IRD [F B010067650]
Identifiant IRD
fdi:010067650
Contact