@article{fdi:010066957,
  title = {{E}scaping deleterious immune response in their hosts : lessons from {T}rypanosomatids},
  author = {{G}eiger, {A}nne and {B}ossard, {G}. and {S}ereno, {D}enis and {P}issarra, {J}. and {L}emesre, {J}ean-{L}oup and {V}incendeau, {P}. and {H}olzmuller, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {T}rypanosomatidae family includes the genera {T}rypanosome and {L}eishmania, protozoan parasites displaying complex digenetic life cycles requiring a vertebrate host and an insect vector. {T}rypanosome brucei gambiense, {T}rypanosorna cruzi, and {L}eishmania spp. are important human pathogens causing human {A}frican trypanosomiasis ({HAT} or sleeping sickness), {C}hagas' disease, and various clinical forms of {L}eishmaniasis, respectively. {T}hey are transmitted to humans by tsetse flies, triatomine bugs, or sandflies, and affect millions of people worldwide. {I}n humans, extracellular {A}frican trypanosomes ({T}. brucei) evade the hosts' immune defenses, allowing their transmission to the next host, via the tsetse vector. {B}y contrast, {T}. cruzi and {L}eishmania sp. have developed a complex intracellular lifestyle, also preventing several mechanisms to circumvent the host's immune response. {T}his review seeks to set out the immune evasion strategies developed by the different trypanosomatids resulting from parasite-host interactions and will focus on: clinical and epidemiological importance of diseases; life cycles: parasites-hosts-vectors; innate immunity: key steps for trypanosomatids in invading hosts; deregulation of antigen-presenting cells; disruption of efficient specific immunity; and the immune responses used for parasite proliferation.},
  keywords = {{T}rypanosomatidae family ; parasite-host interactions ; immunosuppression ; {L}eishmania sp. ; {T}rypanosoma brucei sp. ; {T}rypanosome cruzi},
  booktitle = {},
  journal = {{F}rontiers in {I}mmunology},
  volume = {7},
  numero = {},
  pages = {art. 212 [ p.]},
  ISSN = {1664-3224},
  year = {2016},
  DOI = {10.3389/fimmu.2016.00212},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066957},
}