%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Tissot, T.
%A Ujvari, B.
%A Solary, E.
%A Lassus, P.
%A Roche, Benjamin
%A Thomas, F.
%T Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems ?
%D 2016
%L fdi:010066926
%G ENG
%J Biochimica et Biophysica Acta : Reviews on Cancer
%@ 0304-419X
%K Evolution ; Ecology ; Non-cell-autonomous effects ; Mutations ; Cancer
%M ISI:000376546200006
%N 2
%P 147-154
%R 10.1016/j.bbcan.2016.01.005
%U https://www.documentation.ird.fr/hor/fdi:010066926
%> https://www.documentation.ird.fr/intranet/publi/2016/06/010066926.pdf
%V 1865
%W Horizon (IRD)
%X By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.
%$ 020 ; 050