@article{fdi:010066926,
  title = {{D}o cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems ?},
  author = {{T}issot, {T}. and {U}jvari, {B}. and {S}olary, {E}. and {L}assus, {P}. and {R}oche, {B}enjamin and {T}homas, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}y definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. {A}ctually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. {I}n addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. {H}ere, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. {I}ntegrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.},
  keywords = {{E}volution ; {E}cology ; {N}on-cell-autonomous effects ; {M}utations ; {C}ancer},
  booktitle = {},
  journal = {{B}iochimica et {B}iophysica {A}cta : {R}eviews on {C}ancer},
  volume = {1865},
  numero = {2},
  pages = {147--154},
  ISSN = {0304-419{X}},
  year = {2016},
  DOI = {10.1016/j.bbcan.2016.01.005},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066926},
}