Tissot T., Ujvari B., Solary E., Lassus P., Roche Benjamin, Thomas F. (2016). Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems ?. Biochimica et Biophysica Acta : Reviews on Cancer, 1865 (2), p. 147-154. ISSN 0304-419X.
Titre du document
Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems ?
Tissot T., Ujvari B., Solary E., Lassus P., Roche Benjamin, Thomas F.
Source
Biochimica et Biophysica Acta : Reviews on Cancer, 2016,
1865 (2), p. 147-154 ISSN 0304-419X
By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
