@article{fdi:010066918,
  title = {{E}vidence for widespread infection of {A}frican bats with {C}rimean-{C}ongo hemorrhagic fever-like viruses},
  author = {{M}uller, {M}. {A}. and {D}evignot, {S}. and {L}attwein, {E}. and {C}orman, {V}. {M}. and {M}aganga, {G}. {D}. and {G}loza-{R}ausch, {F}. and {B}inger, {T}. and {V}allo, {P}. and {E}mmerich, {P}. and {C}ottontail, {V}. {M}. and {T}schapka, {M}. and {O}ppong, {S}. and {D}rexler, {J}. {F}. and {W}eber, {F}. and {L}eroy, {E}ric and {D}rosten, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}rimean {C}ongo hemorrhagic fever virus ({CCHFV}) is a highly virulent tick-borne pathogen that causes hemorrhagic fever in humans. {T}he geographic range of human {CCHF} cases largely reflects the presence of ticks. {H}owever, highly similar {CCHFV} lineages occur in geographically distant regions. {T}ick-infested migratory birds have been suggested, but not confirmed, to contribute to the dispersal. {B}ats have recently been shown to carry nairoviruses distinct from {CCHFV}. {I}n order to assess the presence of {CCHFV} in a wide range of bat species over a wide geographic range, we analyzed 1,135 sera from 16 different bat species collected in {C}ongo, {G}abon, {G}hana, {G}ermany, and {P}anama. {U}sing a {CCHFV} glycoprotein-based indirect immunofluorescence test ({IIFT}), we identified reactive antibodies in 10.0% (114/1,135) of tested bats, pertaining to 12/16 tested species. {D}epending on the species, 3.6%-42.9% of cave-dwelling bats and 0.6%-7.1% of foliage-living bats were seropositive (two-tailed t-test, p = 0.0447 cave versus foliage). 11/30 {IIFT}-reactive sera from 10 different {A}frican bat species had neutralizing activity in a virus-like particle assay. {N}eutralization of full {CCHFV} was confirmed in 5 of 7 sera. {W}idespread infection of cave-dwelling bats may indicate a role for bats in the life cycle and geographic dispersal of {CCHFV}.},
  keywords = {{CONGO} ; {GABON} ; {GHANA} ; {ALLEMAGNE} ; {PANAMA}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {6},
  numero = {},
  pages = {art. 26637 [10 p.]},
  ISSN = {2045-2322},
  year = {2016},
  DOI = {10.1038/srep26637},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066918},
}