Publications des scientifiques de l'IRD

Frumence E., Roche M., Krejbich-Trotot P., El-Kalamouni C., Nativel B., Rondeau P., Missé Dorothée, Gadea G., Viranaicken W., Desprès P. (2016). The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-beta production and apoptosis induction. Virology, 493, p. 217-226. ISSN 0042-6822.

Titre du document
The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-beta production and apoptosis induction
Année de publication
2016
Type de document
Article référencé dans le Web of Science WOS:000375824300021
Auteurs
Frumence E., Roche M., Krejbich-Trotot P., El-Kalamouni C., Nativel B., Rondeau P., Missé Dorothée, Gadea G., Viranaicken W., Desprès P.
Source
Virology, 2016, 493, p. 217-226 ISSN 0042-6822
Zika virus (ZIKV) is an emerging flavivirus since the first epidemics in South Pacific in 2007. The recent finding that ZIKV is now circulating in Western Hemisphere and can be associated to severe human diseases, warrants the need for its study. Here we evaluate the susceptibility of human lung epithelial A549 cells to South Pacific epidemic strain of ZIKV isolated in 2013. We showed that ZIKV growth in A549 cells is greatly efficient. ZIKV infection resulted in the secretion of IFN-beta followed by the expression of pro-inflammatory cytokines such as IL-1 beta, and transcriptional activity of IFIT genes. At the maximum of virus progeny production, ZIKV triggers mitochondrial apoptosis through activation of caspases-3 and -9. Whereas at early infection times, the rapid release of IFN-1 beta which exerts an antiviral effect against ZIKV might delay apoptosis in infected cells.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
POLYNESIE FRANCAISE ; PACIFIQUE SUD
Localisation
Fonds IRD [F B010066903]
Identifiant IRD
fdi:010066903
Contact