@article{fdi:010066901,
  title = {{I}ncreased gut redox and depletion of anaerobic and methanogenic prokaryotes in severe acute malnutrition [article r{\'e}tract{\'e}]},
  author = {{M}illion, {M}. and {A}lou, {M}. {T}. and {K}helaifia, {S}. and {B}achar, {D}. and {L}agier, {J}. {C}. and {D}ione, {N}. and {B}rah, {S}. and {H}ugon, {P}. and {L}ombard, {V}. and {A}rmougom, {F}abrice and {F}romonot, {J}. and {R}obert, {C}. and {M}ichelle, {C}. and {D}iallo, {A}. and {F}abre, {A}. and {G}uieu, {R}. and {S}okhna, {C}heikh and {H}enrissat, {B}. and {P}arola, {P}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{S}evere acute malnutrition ({SAM}) is associated with inadequate diet, low levels of plasma antioxidants and gut microbiota alterations. {T}he link between gut redox and microbial alterations, however, remains unexplored. {B}y sequencing the gut microbiomes of 79 children of varying nutritional status from three centers in {S}enegal and {N}iger, we found a dramatic depletion of obligate anaerobes in malnutrition. {T}his was confirmed in an individual patient data meta-analysis including 107 cases and 77 controls from 5 different {A}frican and {A}sian countries. {S}pecifically, several species of the {B}acteroidaceae, {E}ubacteriaceae, {L}achnospiraceae and {R}uminococceae families were consistently depleted while {E}nterococcus faecalis, {E}scherichia coli and {S}taphylococcus aureus were consistently enriched. {F}urther analyses on our samples revealed increased fecal redox potential, decreased total bacterial number and dramatic {M}ethanobrevibacter smithii depletion. {I}ndeed, {M}. smithii was detected in more than half of the controls but in none of the cases. {N}o causality was demonstrated but, based on our results, we propose a unifying theory linking microbiota specificity, lacking anaerobes and archaea, to low antioxidant nutrients, and lower food conversion.},
  keywords = {{SENEGAL} ; {NIGER}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {6},
  numero = {},
  pages = {26051 [11  + r{\'e}tractation : 2023, 13, 18589, 1 p.]},
  ISSN = {2045-2322},
  year = {2016},
  DOI = {10.1038/srep26051},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066901},
}