Yerbanga R. S., Rayaisse J. B., Vantaux Amélie, Salou E., Mouline Karine, Hien F., Habluetzel A., Dabiré R. K., Ouédraogo J. B., Solano Philippe, Lefèvre T. (2016). Neemazal (R) as a possible alternative control tool for malaria and African trypanosomiasis ?. Parasites and Vectors, 9, p. art. 263 [14 p.]. ISSN 1756-3305.
Titre du document
Neemazal (R) as a possible alternative control tool for malaria and African trypanosomiasis ?
Année de publication
2016
Auteurs
Yerbanga R. S., Rayaisse J. B., Vantaux Amélie, Salou E., Mouline Karine, Hien F., Habluetzel A., Dabiré R. K., Ouédraogo J. B., Solano Philippe, Lefèvre T.
Source
Parasites and Vectors, 2016,
9, p. art. 263 [14 p.] ISSN 1756-3305
Background: Research efforts to identify possible alternative control tools for malaria and African trypanosomiasis are needed. One promising approach relies on the use of traditional plant remedies with insecticidal activities. Methods: In this study, we assessed the effect of blood treated with different doses of NeemAzal (R) (NA, neem seed extract) on mosquitoes (Anopheles coluzzii) and tsetse flies (Glossina palpalis gambiensis) (i) avidity to feed on the treated blood, (ii) longevity, and (iii) behavioural responses to human and calf odours in dual-choice tests. We also gauged NeemAzal (R) toxicity in mice. Results: In An. coluzzii, the ingestion of NA in bloodmeals offered by membrane feeding resulted in (i) primary antifeedancy; (ii) decreased longevity; and (iii) reduced response to host odours. In G. palpalis gambiensis, NA caused (i) a knock-down effect; (ii) decreased or increased longevity depending on the dose; and (iii) reduced response to host stimuli. In both cases, NA did not affect the anthropophilic rate of activated insects. Overall, the most significant effects were observed with NA treated bloodmeals at a dose of 2000 mu g/ml for mosquitoes and 50 mu g/ml for tsetse flies. Although no mortality in mice was observed after 14 days of follow-up at oral doses of 3.8, 5.6, 8.4 and 12.7 g/kg, behavioural alterations were noticed at doses above 8 g/kg. Conclusion: This study revealed promising activity of NA on A. coluzzii and G. palpalis gambiensis but additional research is needed to assess field efficacy of neem products to be possibly integrated in vector control programmes.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
;
Sciences du monde végétal [076]
;
Sciences du monde animal [080]
Description Géographique
BURKINA FASO ; AFRIQUE SUBSAHARIENNE
Localisation
Fonds IRD [F B010066896]
Identifiant IRD
fdi:010066896
