@article{fdi:010066886,
  title = {{P}hylogenetic analysis of a newfound bat-borne hantavirus supports a laurasiatherian host association for ancestral mammalian hantaviruses [+ {C}orrigendum {IGE}.2019, {V}ol. 67, p. 247]},
  author = {{W}itkowski, {P}. {T}. and {D}rexler, {J}. {F}. and {K}allies, {R}. and {L}ickova, {M}. and {B}okorova, {S}. and {M}ananga, {G}. {D}. and {S}zemes, {T}. and {L}eroy, {E}ric and {K}ruger, {D}. {H}. and {D}rosten, {C}. and {K}lempa, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{U}ntil recently, hantaviruses (family {B}unyaviridae) were believed to originate from rodent reservoirs. {H}owever, genetically distinct hantaviruses were lately found in shrews and moles, as well as in bats from {A}frica and {A}sia. {B}ats (order {C}hiroptera) are considered important reservoir hosts for emerging human pathogens. {H}ere, we report on the identification of a novel hantavirus, provisionally named {M}akokou virus ({MAKV}), in {N}oack's {R}oundleaf {B}at ({H}ipposideros ruber) in {G}abon, {C}entral {A}frica. {P}hylogenetic analysis of the genomic {L}-segment showed that {MAKV} was the most closely related to other bat-borne hantaviruses and shared a most recent common ancestor with the {A}sian hantaviruses {X}uan {S}on and {L}aibin. {B}reakdown of the virus load in a bat animal showed that {MAKV} resembles rodent-borne hantaviruses in its organ distribution in that it predominantly occurred in the spleen and kidney; this provides a first insight into the infection pattern of bat-borne hantaviruses. {A}ncestral state reconstruction based on a tree of {L} gene sequences of all relevant hantavirus lineages was combined with phylogenetic fossil host hypothesis testing, leading to a statistically significant rejection of the mammalian superorder {E}uarchontoglires (including rodents) but not the superorder {L}aurasiatheria (including shrews, moles, and bats) as potential hosts of ancestral hantaviruses at most basal tree nodes. {O}ur data supports the emerging concept of bats as previously overlooked hantavirus reservoir hosts.},
  keywords = {{A}frica ; {B}at ; {H}antavirus ; {L}aurasiatheria ; {M}akokou virus ; {Z}oonosis ; {GABON}},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {41},
  numero = {},
  pages = {113--119 [+ {C}orrigendum {IGE}.2019, {V}ol. 67, p. 247]},
  ISSN = {1567-1348},
  year = {2016},
  DOI = {10.1016/j.meegid.2016.03.036},
  URL = {https://www.documentation.ird.fr/hor/fdi:010066886},
}